Top 4 Prop Bets for Rams–49ers Thursday Night Football

Thursday Night Football brings an NFC West clash as the Rams ride momentum into Levi’s Stadium against a 49ers squad dealing with quarterback uncertainty. Los Angeles has covered four straight against San Francisco and looks sharper on both sides of the ball. The Rams rank third in passing yards per game and tenth in defensive efficiency, while the 49ers have leaned heavily on their ground attack behind Christian McCaffrey. That sets up a tight game where individual player props offer clear value. Here are four sharp props to target.

Christian McCaffrey – Over 16.5 Rushing Attempts

San Francisco’s passing game could be limited if Brock Purdy sits or plays at less than full strength. Even if he goes, Purdy remains mistake-prone, and Kyle Shanahan tends to lean on McCaffrey in these situations. McCaffrey has averaged 20.3 touches per game this season, and with the Rams ranking ninth in run defense, the 49ers will need volume on the ground rather than efficiency. Given San Francisco’s run-heavy strategy, especially on the road, this number seems too low.

DraftKings

4.6/5

Tip: Bet Christian McCaffrey over 16.5 rushing attempts

• Release Option
• Active un the Passing game
• Cowboy Pass Defense Soft

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Puka Nacua – Under 101.5 Rushing + Receiving Yards

Nacua has been one of the breakout stars of 2025, averaging 125.8 receiving yards per game. That’s inflated his props, and this matchup tilts toward the under. The 49ers allow only 165 passing yards per game, good for sixth in the league, and defensive coordinator Robert Saleh will scheme to bracket Nacua after his string of explosive outings. While Stafford will feed his top wideout, expecting him to clear 100 combined rushing and receiving yards against one of the NFL’s stingiest secondaries is a big ask. Regression against elite defenses is the sharp side here.

BetMGM

4.5/5

Tip: Bet Puka Nacua – Under 101.5 Rushing + Receiving Yards

• Leads Team, in targets
• Consistency
• Cowboys Secondary Vulnerable Vulnerable

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Matthew Stafford – Over 21.5 Completions

Stafford just threw for 375 yards and three touchdowns, and the Rams’ offense is humming at 6.3 yards per play, third-best in the NFL. The 49ers’ secondary limits deep shots, but that sets up perfectly for Stafford to rack up completions on short and intermediate routes. Even in his struggles against San Francisco since 2021—seven touchdowns and seven interceptions in seven games—Stafford has averaged high pass volume. With Kyren Williams softening the front and Nacua drawing coverage attention, Stafford clearing 22 completions looks like the safer angle than yards.

FanDuel

4.6/5

Tip: Bet Matthew Stafford – Over 21.5 Completions

• Volume favors Pickens
• Cee Dee Lamb Out
• Picks heavy intermediate routes

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Davante Adams – Anytime Touchdown (+115)

Adams has been consistent in the red zone regardless of matchup, and San Francisco’s defense has shown cracks in coverage without edge rusher Nick Bosa generating pressure. Adams owns a 47% red zone target share through the first month of the season, ranking just behind Amon-Ra St. Brown and Nico Collins. That usage is elite and underscores his scoring upside. With his crisp routes and contested-catch ability, Adams can win against any 49ers defensive back. At plus money, his anytime touchdown stands out as one of the best values on the board.

Conclusion

This matchup tilts toward a lower-scoring, grind-it-out game. McCaffrey’s workload projects up, Nacua’s yardage should regress, Stafford’s completions are set to climb, and Adams’ touchdown threat remains live. The Rams have momentum and matchup edges, but the props highlight individual pathways where bettors can profit regardless of who controls the scoreboard.