NFL Preseason Detroit Lions vs Los Angeles Chargers Odds, Tips and Predictions 07-31-25

Here’s a comprehensive betting preview for tonight’s Chargers vs. Lions Hall of Fame Game on Thursday, July 31, 2025, at 8 p.m. ET from Canton, Ohio, on NBC

Los Angeles Chargers vs Detroit Lions

• Point Spread: Lions -1.5
• Moneyline Lions -135
• Moneyline Chargers +110
• Over/Under 32.5

🔍 Team & Game Context

Los Angeles Chargers

• Justin Herbert sits out; Trey Lance expected to start into the third quarter, followed by DJ Uiagalelei or Taylor Heinicke.

• Offense leans into rookie talents: Omarion Hampton (RB), Tre Harris, KeAndre Lambert‑Smith gaining early reps.

• The coaching staff under Jim Harbaugh favors a run-heavy, physical identity; the defense is still strong despite losing Joey Bosa.

Detroit Lions

• Coming off a franchise‑best 15‑2 season, though, both coordinators have been replaced this offseason (Ben Johnson & Aaron Glenn departed).

• Jared Goff is likely inactive; snaps are expected from Hendon Hooker and Kyle Allen, with depth players like Tate Ratledge and Tyleik Williams also likely as surprises.

• Dan Campbell is managing starter usage; most vets will not play, reserving evaluation for depth and scheme integration.

Chargers vs Lions Moneyline

• Chargers have multiple QBs eager to prove themselves; rookies getting significant reps can tilt upside toward L.A.

• Underdogs have won the HOF Game the last three seasons, making this type of pick more appealing

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DraftKings

4.5/5

Tip: Bet Chargers +1.5

• Chargers to play more starters
• Turnovers to be key
• Game in Canton

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Chargers vs Lions Over/Under 32.5

• Last three HOF Games: 37+ combined points each, despite low preseason totals set at ~32.5–33.

• Public overwhelmingly betting the Over; this trend lines up with expert picks advocating an over result again

DraftKings

4.5/5

Tip: Bet the Over 32.5

• Chargers to play the better QBs
• Chargers style more conducive to Preseason
• Game in Canton

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🎯 Final Pick(s)

• Primary: Over 32.5 (+110) — expect atypical scoring bursts even in preseason settings.

• Secondary: Chargers moneyline at +115 — strong upside play as underdogs with motivational edge on roster cut auditions.

⚠ Key Notes & Caveats

• Starter availability is low: both teams treating this as depth showcase rather than full competitive tilt.

• Limited regular-season inference: performance tonight may be more indicative of camp battles than true season form.

Best Bet Over 32.5