Buffalo will need to contain Tyreek Hill and Jaylen Waddle, who racked up 100 yards each in Week 1 – can the Bills disrupt that timing? Josh Allen spread the ball among different receivers while James Cook gained 103 total yards on running plays alone for Buffalo. Miami is currently 1-5 against them under Mike McDaniel; however, Thursday Night Football stage makes this matchup unpredictable. The Dolphins look to be the better team overall in this one.
Prediction: Miami 34 Buffalo 24
DraftKings
4.5/5
Tip: Bet Miami -2
Two High-Powered Offenses
Miami at home
Dolphins to win through the passing game
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New Orleans vs Dallas
Point Spread: Dallas -6.5
Moneyline Buffalo +250
Moneyline Miami -310
Over/Under 46.5
Dallas triumphed 27-17 at Caesars Superdome during their last meeting, and we can expect something similar tonight. The Saints and Cowboys were both dominating in their season openers. Getting to the quarterback decides this game. Expect a close game, as the Saints will be looking to prove they are for real.
Prediction: Dallas 31 New Orleans 24
DraftKings
4.5/5
Tip: Bet Dallas -6.5
Two High-Powered Offenses
Dallas at home
Dak Prescott to be the difference
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Tampa Bay vs Detroit
Point Spread: Detroit -7
Moneyline Tampa Bay +260
Moneyline Detroit -320
Over/Under 51.5
Rematch of an NFC Divisional playoff from last season promises to be exciting. Baker Mayfield had 289 yards and four touchdowns in Week 1, but took four sacks and threw two interceptions in Detroit’s 31-23 playoff loss last year. David Montgomery and Jahmyr Gibbs’ relentless running game accumulated 163 yards during Week 1, proving a pivotal element to Detroit’s win – while Mayfield may even have the chance at scoring a late game-winner.
Prediction: Detroit 33 Tampa Bay 27
DraftKings
4.5/5
Tip: Bet Tampa Bay +7
Expect a lot of points
Detroit at home
Lions run game will decide winner
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Cleveland vs Jacksonville
Point Spread: Jaguars -3.5
Moneyline Cleveland +146
Moneyline Jaguars -174
Over/Under 41.5
Deshaun Watson of Cleveland completed just 53.3 percent of his passes in their opening game against Dallas; Myles Garrett recorded one of three sacks for the Browns; Trevor Lawrence completed 57.1 percent in Miami, while Travon Walker recorded two sacks. These teams have similar strengths and weaknesses, which make this matchup close. We will pick the home team.
Prediction: Jacksonville 27 Cleveland 20
DraftKings
4.5/5
Tip: Bet Cleveland -3.5
Trevor lawrence to play well
Jacksonville at home
Jaguars run game will decide winner
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San Fransisco vs Minnesota
Point Spread: 49ers -6.5
Moneyline 49ers -270
Moneyline Vikings +220
Over/Under 45.5
Sam Darnold led an error-free performance for Minnesota hitting Justin Jefferson for a touchdown and Aaron Jones excelling as an all-purpose back. Although their offense appears functional enough to beat non-Super Bowl contenders like Washington or Atlanta, will it hold up against Super Bowl contenders like the 49ers?
Prediction: San Fransisco 33 Minnesota 17
DraftKings
4.5/5
Tip: Bet 49ers -6.5
Brock Purdy will play well
Minnesota at home
Sam Darnold to struggle
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Los Angeles Chargers vs Carolina Panthers
Point Spread: Chargers -6.5
Moneyline Chargers -295
Moneyline Panthers +240
Over/Under 38.5
Jim Harbaugh led his Chargers to victory in Week 1, with JK Dobbins recording 135 yards. Harbaugh will look to use running plays to open up more vertical shots for Justin Herbert, Carolina gave up 180 rushing yards last week! The Chargers dominate on the ground in this one.
Prediction: Chargers 37 Panthers 10
DraftKings
4.5/5
Tip: Bet Chargers -6.5
Dobbins will play well
Carolina at home
Justin Herbert with two plus TD passes
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Las Vegas vs Baltimore
Point Spread: Ravens -9.5
Moneyline Raiders +385
Moneyline Panthers -500
Over/Under 41.5
The highest line of the week belongs to this game as Baltimore amassed 452 yards against Kansas City last week in Week 1, leading Lamar Jackson’s offense with Derrick Henry on the ground and tight end Isaiah Likely’s nine receptions for 111 yards and one TD catch in Week 1.
Prediction: Baltimore 27 Las Vegas 16
DraftKings
4.5/5
Tip: Bet Ravens -9.5
Jackson will play well
Baltimore at home
Minshew to struggle
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LA Rams vs Arizona Cardinals
Point Spread: Cardinals -2
Moneyline Rams +100
Moneyline Cardinals =118
Over/Under 49.5
Kyler Murray will need to incorporate rookie receiver Marvin Harrison Jr. more fully in their offense after seeing only three targets and one reception in his debut. Meanwhile, the Los Angeles Rams passed for 317 yards with only two sacks taken against them against Detroit; Cooper Kupp caught 14 passes for 110 yards and scored one TD.
Prediction: Rams 27 Cardinals 24
DraftKings
4.5/5
Tip: Bet Rams +2
Stafford playing well
Cardinals at home
Harrison needs to be more involved
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Pittsburgh vs Denver
Point Spread: Steelers -2.5
Moneyline Steelers -148
Moneyline Broncos +126
Over/Under 36.5
Pittsburgh has struggled in Denver in the past four trips yet won its opening game with an outstanding defensive effort that forced three turnovers. Justin Fields was efficient without giving away possession. Rookie quarterback Bo Nix will need to minimize mistakes when facing J.J. Watt, who recorded one sack and two tackles for loss last week.
Prediction: Pittsburgh 16 Denver 13
DraftKings
4.5/5
Tip: Bet Steelers -2.5
Steelers defense is playing well
Broncos at home
Bo Levi needs to play well
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Cincinnati vs Kansas City
Point Spread: Chiefs -5.5
Moneyline Bengals +194
Moneyline Chiefs -235
Over/Under 47.5
Joe Burrow and Ja’Marr Chase will look to build off of Chase’s six catches for 62 yards in Week 1. Patrick Mahomes comes through again when needed, and Cincinnati falls to 0-2, with Mahomes averaging 245.6 yards per game while scoring nine touchdowns and only two interceptions against them over their past five meetings; making this game filled with playoff intensity; the Bengals are not the same team at the start of the season and that will be painfully obvious in this game.
Prediction: Kansas City 30 Cincinnati 17
DraftKings
4.5/5
Tip: Bet Chiefs -5.5
Bengals look unprepared
Chiefs at home
Pacheco runs wild
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Chicago vs Houston
Point Spread: Texans -6.5
Moneyline Bears +220
Moneyline Texans -270
Over/Under 45.5
Caleb Williams will make his Sunday Night Football debut for Houston against Houston’s C.J. Stroud, who boasts an outstanding 108.3 QB rating at home and a 5-5 ATS record since last season. While Williams may show improvement and have his moments, Stroud will throw more touchdown passes, and Joe Mixon may score one as well.
Prediction: Houston 31 Chicago 16
DraftKings
4.5/5
Tip: Bet Texans -6.5
Stroud to dominate
Texans at home
Mixon runs wild
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New York vs Washington
Point Spread: Commanders -1.5
Moneyline Giants -102
Moneyline Commanders -116
Over/Under 43.5
Both teams have offensive issues, with Jayden Daniels offering some threat on the ground; he amassed 88 rushing yards and one touchdown during Week 1. As opposed to this week, Daniel Jones attempted 42 passes with two interceptions on Sunday against the Minnesota Vikings. the Giants are a bad football team, the Commanders are not much better but they are better.
Prediction: Washington 24 Giants 17
DraftKings
4.5/5
Tip: Bet Commanders -1.5
Daniels will play better
Commanders at home
Close game
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Seattle vs New England
Point Spread: Seahawks -3.5
Moneyline Seahawks -210
Moneyline Patriots +176
Over/Under 38.5
The Patriots scored an upset on the road last week. Now, can they make it two straight victories under new coach Jerod Mayo in his home debut, as Seattle coach Mike Macdonald is also trying to do? Geno Smith passed for 171 yards and one touchdown, while Kenneth Walker III ran for 103. New England limited Cincinnati to only 224 total yards with their defense, while Rhamondre Stevenson rushed 120 yards with a score.
Prediction: New England 16 Seattle 14
DraftKings
4.5/5
Tip: Bet Patriots +3.5
Patriots defense is good
Patriots at home
Geno Smith to struggle
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Indianapolis vs Green Bay
Point Spread: Colts -3
Moneyline Colts -154
Moneyline Packers +130
Over/Under 41
This line shifted dramatically after Jordan Love’s injury; Malik Willis will use a low-risk passing attack in his first start for Green Bay. Anthony Richardson gained 218 passing yards on just nine completions last week; Green Bay will need to stop any big plays made by Anthony Richardson, Brandon Jacobs, or Jonathan Taylor to stay competitive against Green Bay (now 0-2). Green Bay may fall back into an unfamiliar losing streak, but this game should remain close throughout.
Prediction: Indianapolis 23 Green Bay 16
DraftKings
4.5/5
Tip: Bet Colts -3
Packers defense is good
Packers at home
No Jordan Love equals Colts win
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New York vs Tennessee
Point Spread: Jets -3.5
Moneyline Jets -180
Moneyline Titans +152
Over/Under 40.5
The Titans outplayed the Bears but made critical mistakes, while the Jets showed that their defense was not as great as predicted. I expect a close game in this one that goes down to the wire.
Prediction: Titans 23 Jets 20
DraftKings
4.5/5
Tip: Bet Titans +3.5
Jets defense is good
Titans at home
Rodgers will play well
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Atlanta vs Philadelphia
Point Spread: Eagles -6.5
Moneyline Falcons +260
Moneyline Eagles -320
Over/Under 47.5
The Falcons may be at risk of going 0-2 with Kirk Cousins under center, who did not play well in week one. Meanwhile, Jalen Hurts appears to have developed into a more dangerous QB with the addition of Saquon Barkley (132 total yards) and Bijan Robinson (113 total yards) as additions for Jalen Hurts’ offense.
Prediction: Eagles 27 Falcons 20
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Tip: Bet Eagles -6.5
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