Dallas Cowboys at Indianapolis Colts 2026 Preview: Prediction, Betting Odds & 4 Prop Bets

The Dallas Cowboys travel to Lucas Oil Stadium on Sunday, November 8, 2026, looking to rebound from a heartbreaking overtime defeat when they face the struggling Indianapolis Colts.

Dallas enters 3-5 following a 33-30 overtime loss to Arizona, while Indianapolis sits at 2-6 after suffering an embarrassing 42-7 defeat against Jacksonville.

Both teams desperately need a victory, but the Cowboys enter as six-point road favorites behind quarterback Dak Prescott and an offense featuring CeeDee Lamb, George Pickens and Javonte Williams.

Game Information

Matchup: Dallas Cowboys at Indianapolis Colts Date: Sunday, November 8, 2026 Kickoff: 1:00 PM ET TV: FOX Venue: Lucas Oil Stadium — Indianapolis, Indiana Tickets: As low as $110 Records: Dallas 3-5 | Indianapolis 2-6 Point Spread: Dallas -6 Over/Under: 51.5

The Dallas -6 spread means the Cowboys must win by seven points or more to cover. A Dallas victory by exactly six points results in a push. Indianapolis +6 covers if the Colts win outright or lose by five points or fewer.

The 51.5 over/under means the teams must combine for at least 52 points for an over wager to win.

Dallas: Prescott Looks to Rebound After Overtime Collapse

The Cowboys enter Indianapolis needing to recover from one of their most frustrating defeats of the season.

Dallas led Arizona by 14 points early in the fourth quarter before allowing the Cardinals to rally for a 33-30 overtime victory.

Quarterback Dak Prescott completed 19 of 29 passes for 195 yards and a touchdown. He also rushed for 20 yards and another score.

Through eight games, Prescott has thrown for 2,046 yards, 14 touchdowns and five interceptions, completing 65.2 percent of his passes.

Receiver CeeDee Lamb remains Dallas’ premier offensive weapon, entering the matchup with 709 receiving yards. George Pickens provides another dangerous option, contributing 533 receiving yards.

Running back Javonte Williams has rushed for 528 yards and eight touchdowns, providing the Cowboys with a dependable rushing attack.

Dallas’ greatest concern remains its defensive inconsistency.

Against Arizona, the Cowboys surrendered 467 total yards, including 202 rushing yards. The Cardinals scored touchdowns on four consecutive possessions late in regulation.

Defensive tackle Quinnen Williams recorded two sacks and has become an important part of Dallas’ pass rush.

The Cowboys need a more disciplined performance, particularly when protecting a second-half lead.

Indianapolis: Colts Searching for Answers After Jacksonville Disaster

Indianapolis enters Sunday having lost four consecutive games, with its latest defeat exposing problems on both sides of the football.

The Colts trailed Jacksonville 28-0 at halftime and eventually lost 42-7.

Quarterback Daniel Jones completed 19 of 28 passes for 144 yards, one touchdown and two interceptions.

Jones has thrown for 1,542 yards, five touchdowns and nine interceptions this season, with turnovers becoming a major concern.

Running back Jonathan Taylor remains Indianapolis’ most important offensive weapon.

Taylor has rushed for 610 yards and eight touchdowns, although Jacksonville limited him to just 23 yards on eight carries.

Receiver Josh Downs has contributed 330 receiving yards, while veteran Keenan Allen has added 325 yards.

Indianapolis must also adjust to significant changes along its offensive and defensive lines following the departures of Quenton Nelson and DeForest Buckner.

The Colts allowed Jacksonville to average nearly seven yards per play, an alarming statistic entering a matchup against Prescott and Dallas’ talented receivers.

If Indianapolis cannot protect Jones or establish Taylor, another difficult afternoon could follow.

Four Prop Bets to Consider

The following are projected betting targets, not confirmed sportsbook player-prop lines. Availability and odds vary by sportsbook. Verify the final injury reports before wagering.

Prop Bet #1: Dak Prescott Over 249.5 Passing Yards

DraftKings

4.5/5

Tip: Prescott Over 249.5 Passing Yards

• 2,046 Season Passing Yards
• 14 Passing TDs
• Indianapolis Defensive Struggles

New DraftKings Customers: Bet $5, Get $200 + 3 Months of NBA League Pass

Get bonus now

Prescott should have opportunities against a Colts defense that struggled badly against Jacksonville.

With Lamb and Pickens creating mismatches, Dallas can attack Indianapolis through the air.

Prediction: Dak Prescott — 287 passing yards

Prop Bet #2: CeeDee Lamb Over 84.5 Receiving Yards

FanDuel

4.6/5

Tip: Lamb Over 84.5 Receiving Yards

• 709 Season Receiving Yards
• Dallas Primary Receiver
• Explosive Playmaking Ability

New Users – Get $200 in Bonus Bets when you wager $5 for 4 days

Get bonus now

Lamb remains Prescott’s most reliable receiving weapon.

Indianapolis may struggle to contain his combination of route-running, acceleration and yards-after-catch ability.

Prediction: CeeDee Lamb — 103 receiving yards

Prop Bet #3: Javonte Williams Over 64.5 Rushing Yards

Caesars

4.4/5

Tip: Williams Over 64.5 Rushing Yards

• 528 Season Rushing Yards
• 8 Rushing TDs
• Arizona Ran for 202 Yards vs Dallas

Bet $1 and get double the winnings up to $25 for your next 10 bets

–

Williams gives Dallas an opportunity to establish offensive balance against a struggling Indianapolis defense.

If Dallas builds an early advantage, expect Williams to receive additional second-half carries.

Prediction: Javonte Williams — 81 rushing yards

Prop Bet #4: Jonathan Taylor Over 69.5 Rushing Yards

BetMGM

4.5/5

Tip: Taylor Over 69.5 Rushing Yards

• 610 Season Rushing Yards
• 8 Rushing TDs
• Dallas Allowed 202 Rush Yards vs Arizona

Get Up to $1,000 Back in Bonus Bets Over Your First 10 Days

Get bonus now

Taylor needs a bounce-back performance after being limited to 23 yards against Jacksonville.

Dallas’ difficulties stopping Arizona’s rushing attack suggest Indianapolis could find opportunities on the ground.

Prediction: Jonathan Taylor — 83 rushing yards

Players to Watch

Dak Prescott — Dallas

Prescott must protect the football and capitalize on Indianapolis’ defensive weaknesses. His ability to sustain drives will be critical.

CeeDee Lamb — Dallas

Lamb provides Dallas with explosive playmaking ability and remains the Cowboys’ most dangerous receiving threat.

Jonathan Taylor — Indianapolis

Taylor must establish the running game and help Indianapolis control possession.

Daniel Jones — Indianapolis

Jones needs to eliminate costly interceptions and deliver a more efficient performance.

Keys to the Game

Dallas must protect Prescott, establish Williams early and avoid another late defensive collapse.

The Cowboys should exploit favorable matchups with Lamb and Pickens while forcing Indianapolis into passing situations.

Indianapolis must establish Taylor, improve its pass protection and avoid turnovers.

The Colts also need better third-down execution to prevent Dallas from controlling possession.

Betting Prediction

The Dallas -6 spread reflects the Cowboys’ offensive advantages and Indianapolis’ recent struggles.

Dallas has the stronger passing attack, while Indianapolis has demonstrated difficulty protecting Jones and containing explosive plays.

The 51.5 total presents an interesting opportunity.

Dallas possesses enough offensive firepower to score 30 points, and Indianapolis could contribute offensively if Taylor establishes the run.

Given the defensive struggles of both teams, the over deserves consideration.

The Verdict

Indianapolis should show improvement following its embarrassing loss to Jacksonville, particularly through Taylor’s rushing production.

However, Dallas possesses too many offensive weapons for the Colts to contain consistently.

Prescott finds Lamb and Pickens for important completions, while Williams provides enough rushing production to keep Indianapolis off balance.

The Cowboys pull away in the second half.

Final Score Prediction

Dallas Cowboys 34 Indianapolis Colts 20

Picks Summary

Betting Category Pick Best Bet Dallas -6 Against the Spread Dallas -6 Moneyline Dallas Over/Under Over 51.5 Top Prop CeeDee Lamb Over 84.5 Receiving Yards

Final Prediction: Dallas 34, Indianapolis 20

Dallas wins by 14 points, comfortably covering the six-point spread. The projected 54 combined points finish over the 51.5 total.

The Cowboys improve to 4-5, while Indianapolis falls to 2-7, with Prescott and the Dallas offense delivering an important road victory.