Baltimore Ravens at Indianapolis Colts 2026 Preview: Prediction, Betting Odds & 4 Prop Bets

Sunday, September 13, 2026 Time: 1:00 PM ET Location: Lucas Oil Stadium, Indianapolis, Indiana TV: CBS Tickets: As low as $84 Line: Baltimore -3.5 Moneyline: Baltimore approximately -178 / Indianapolis +149 Over/Under: 47.5

Baltimore begins a new era Sunday when Lamar Jackson and Derrick Henry visit Indianapolis for Jesse Minter’s first regular-season game as Ravens head coach.

Baltimore is trying to rebound from an 8-9 season in which it missed the playoffs despite possessing the NFL’s most productive rushing attack. Henry rushed for 1,595 yards and 16 touchdowns, while Jackson threw for 2,549 yards and 21 touchdowns in 13 starts. Zay Flowers added a Pro Bowl season with 86 receptions for 1,211 yards.

Indianapolis is attempting its own comeback after starting 2025 at 8-2 before injuries helped produce a seven-game losing streak. Daniel Jones is back after tearing his Achilles in December, and Indianapolis says he looked close to his pre-injury form during training camp.

The supplied market remains accurate: Baltimore is -3.5, with a 47.5 total and a moneyline around Ravens -178.

Top Four Prop Bets

Exact player props vary by sportsbook. The numbers below are projected betting targets unless your book offers them.

Prop Bet #1: Derrick Henry Over 89.5 Rushing Yards

DraftKings

4.5/5

Tip: Henry Over 89.5 Rushing Yards

• 1,595 Yards in 2025
• 16 Touchdowns
• Baltimore Run-First Identity

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Henry remains the foundation of Baltimore’s offense after averaging 5.2 yards per carry last season. The Ravens rushed for 2,662 yards as a team, finishing first in the NFL in yards per attempt.

Indianapolis allowed 1,732 rushing yards last season, and Baltimore should test the Colts’ front immediately.

Projected Bet: Derrick Henry Over 89.5 Rushing Yards

Prop Bet #2: Jonathan Taylor Over 79.5 Rushing Yards

FanDuel

4.6/5

Tip: Taylor Over 79.5 Rushing Yards

• 1,585 Yards in 2025
• Healthy Jones Helps Run Game
• Home Opener

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Taylor rushed for 1,585 yards last season, including 1,139 yards over Indianapolis’ first 10 games when the Colts started 8-2.

A healthy Jones forces defenses to respect play-action and should prevent Baltimore from completely selling out against Taylor.

Indianapolis will want to limit Jackson’s possessions by controlling the football.

Projected Bet: Jonathan Taylor Over 79.5 Rushing Yards

Prop Bet #3: Zay Flowers Over 69.5 Receiving Yards

Caesars

4.4/5

Tip: Flowers Over 69.5 Receiving Yards

• 1,211 Yards in 2025
• 118 Targets
• Baltimore’s Top WR

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Flowers averaged 71.2 receiving yards per game last season and clearly established himself as Jackson’s top wide receiver.

Indianapolis upgraded its secondary, but Baltimore should create opportunities for Flowers off play-action once Henry starts influencing the linebackers.

Projected Bet: Zay Flowers Over 69.5 Receiving Yards

Prop Bet #4: Over 47.5 Points

BetMGM

4.5/5

Tip: Over 47.5 Points

• Jackson and Henry
• Colts Offensive Upside
• Two Elite Running Backs

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Indianapolis possessed the NFL’s best offense during the first 10 games of 2025, averaging 31.7 points while scoring on 57.6 percent of its possessions.

Jones is back, Taylor remains elite, Alec Pierce is expected to play after recovering from ankle surgery, and Keenan Allen joins Tyler Warren and Josh Downs in the passing game.

Baltimore has enough firepower to make this a 50-point game.

Bet: Over 47.5 Points

Players to Watch

Lamar Jackson, QB, Ravens: Threw 21 touchdowns against seven interceptions in 13 starts last season.

Derrick Henry, RB, Ravens: Produced 1,595 rushing yards and 16 touchdowns.

Zay Flowers, WR, Ravens: Led Baltimore with 1,211 receiving yards.

Daniel Jones, QB, Colts: Before the 2025 season unraveled, Jones completed 69.8 percent of his passes for 2,659 yards through 10 games.

Jonathan Taylor, RB, Colts: Finished 2025 with 1,585 rushing yards.

Alec Pierce, WR, Colts: Surpassed 1,000 receiving yards and led the NFL at 21.3 yards per reception last season; he is expected to be available Sunday.

Keys to the Game

Baltimore

Baltimore should make Indianapolis stop Henry before asking Jackson to win through the air.

One concern is the offensive line. Jovaughn Gwyn will make his first NFL start at center after winning the job following Tyler Linderbaum’s departure and Danny Pinter’s season-ending injury.

Defensively, new addition Trey Hendrickson could become crucial against Jones. Hendrickson signed a four-year deal after ranking among the NFL’s most productive pass rushers since 2021.

Indianapolis

The Colts must protect Jones and prevent Baltimore from creating obvious passing downs.

Taylor needs 20-plus touches, while Jones should attack with Pierce, Allen and Warren when Baltimore commits extra defenders to stopping the run.

Betting Prediction

Baltimore has the superior quarterback and one of football’s most intimidating rushing attacks, but 3.5 points is meaningful on the road against an Indianapolis team that looked like a legitimate AFC contender before injuries destroyed its 2025 season.

The Colts’ offense should be dangerous again with Jones and Taylor together.

Baltimore is still the more trustworthy team to win outright, but Indianapolis getting more than a field goal at home is attractive.

The Verdict

Expect a physical game built around Henry and Taylor before both quarterbacks begin finding opportunities downfield.

Jackson eventually creates the decisive play late, but Indianapolis keeps it within one possession.

Final Score Prediction: Baltimore Ravens 27, Indianapolis Colts 24

Best Bet: Indianapolis +3.5

Total Pick: Over 47.5

Moneyline: Baltimore

Top Player Prop: Derrick Henry Over 89.5 Rushing Yards

Additional Props: Jonathan Taylor Over 79.5 Rushing Yards | Zay Flowers Over 69.5 Receiving Yards