NCAA Football Indiana Hoosiers vs Ohio State Buckeyes: Odds, Tips and Predictions 11-23-24

The Indiana Hoosiers travel to Columbus, Ohio, in search of victory against Ohio State in a game that will not only put them into the Big Ten Football Championship Game but almost assures a College Football Playoff spot. Who will emerge victorious between the traditional titan and the rising challenger?

Indiana Hoosiers vs Ohio State Buckeyes

• Point Spread: Ohio State -12.5
• Moneyline Indiana +350
• Moneyline Ohio State -465
• Over/Under 52.5

All roads lead to Indiana at Ohio State for a College Football Playoff bid and Big Ten Championship spot.

This is not what we will expected out of this game to start the season.

I was all in favor of Curt Cignetti’s hire, yet I could never have predicted that Indiana would go 10-0 for the first time ever and earn a first-round bye into the College Football Playoff.

They must upset Ohio State at first. Otherwise, their mood and discourse could abruptly change.

According to our Strength of Schedule Metric, Indiana has played the 66th-easiest schedule nationally thus far—far superior to ESPN’s assessment, which placed them with the 100th easiest schedule nationally.

Indiana is playing well despite an easy schedule and has won all but one game by at least two touchdowns.

But should Indiana lose big Saturday, there will be real, understandable discussion over its status as an elite team or are they just like Penn State: one capable of defeating lower-tier Big Ten foes but struggling against top teams.

Indiana may secure its spot in the college football playoff with a strong performance, even in defeat.

As for the game itself, Indiana’s defense shines here. Ohio State is loaded at their skill positions with an average offensive line and slightly above-average quarterback, but Indiana is an underdog in this battleground.

Indiana can win here by limiting possessions and exploiting Ohio State’s errors. I expect Cignetti to take a more relaxed defensive approach than previously, forcing Ohio State’s offensive unit into longer drives instead of allowing explosive plays and potentially forcing mistakes out of the Buckeyes impatience.

Though Ohio State may have more depth and talent at receiver and defensive line positions than Indiana does, the difference is not as big as some believe. Indiana was particularly hampered in its second-half play against Michigan’s front, making almost no progress after halftime. But, the Hoosiers have the correct coach to fix those issues in the week leading up to the game.

Early on, Ohio State may take some time to establish its dominance, as I don’t anticipate them leapfrogging Indiana by an overwhelming margin, but as the game goes along I think the Buckeyes will get stronger. The Hoosiers need to play from the front so first quarter points are a must.

Indiana vs Ohio State Moneyline

Stay off the money line if you are betting Ohio State; Indiana has great moneyline odds and they have a real chance to win this game. To find the best line, you need accounts with multiple sportsbooks, and we got you covered as we break down the best sports betting app

DraftKings

4.5/5

Tip: Bet Indiana +12.5

• Rourke to play well
• Ohio State at home
• The Hoosiers are good

Bet $5, Get $200 + 3 Months of NBA League Pass

Get bonus now

The best NCAA betting sites

To satisfy the ever-growing market of NCAA bettors, the best football sportsbooks offer unique user experiences, huge payouts, and fantastic bonuses. Gamers no longer have to go to casinos to find some physical action. Online bookies let you play the game of risk from the comfort of your own home. We hope our guide can point you in the right direction so you can find the best gambling experiences on the internet.

Best Brand

FanDuel Promo

New Users – Get $200 in Bonus Bets when you wager $5 for 4 days

Get bonus now

Gambling Problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Visit www.mdgamblinghelp.org (MD). 1-888-789-7777 or ccpg.org/chat (CT). Hope is here. GamblingHelpLineMA.org or (800) 327-5050 for 24/7 support (MA). 1-877-8-HOPENY or text HOPENY (467369) (NY). 21+ (18+ D.C., WY) and present in select states (for KS, in affiliation with Kansas Star Casino). First online real money wager only. Min $5 wager required for 4 consecutive days. $5 first deposit required. Bonus issued as nonwithdrawable bonus bets which expire 5 days after receipt. Restrictions apply. See terms at sportsbook.fanduel.com. Call 1-877-770-7867 (LA).

Best Slots

BetMGM Promo

Get Up to $1,000 Back in Bonus Bets Over Your First 10 Days

Get bonus now

Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 21+ only. Please Gamble Responsibly. Visit mdgamblinghelp.org (MD). See BetMGM.com for Terms. New Player Offer for new players only. Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. This promotional offer is not available in NJ, MA, MI, NV, NY, ON, PA, PR, and WV.

Newcomer

DraftKings Promo

Bet $5, Get $200 + 3 Months of NBA League Pass

Get bonus now

GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/NH/PR/WY). Void in CAN. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new Sportsbook customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets. Stake removed from payout. Reward issued as $50 in Bonus Bets every 7 days via click-to-claim for 21 days. Bonus Bets and click-to-claims expire 7 days (168hrs) after issuance. Terms: dkng.co/offer. Get 1 promo code to redeem a 3-month NBA League Pass subscription, complimentary of DraftKings. Subscription auto-renews monthly at then-current price (currently $16.99/mo); cancel anytime. Terms, restrictions, and eligibility requirements apply. Redeem League Pass by 12/19/26 at 11:59 PM ET. Addt’l terms: support.watch.nba.com/hc/en-us/articles/9165532876183-League-Pass-Terms-of-Use_. Ends 11/29/26 at 11:59 PM ET. Sponsored by DK.

Award

Fanatics Promo

Get Up to $1,000 Matched in FanCash

Get bonus now

Must be 21+. GAMBLING PROBLEM? CALL 1-800-GAMBLER OR CALL 1-800-MY-RESET, www.mdgamblinghelp.org (MD), (800)-327-5050 or gamblinghelplinema.org (MA), Call (877)8-HOPENY or text HOPENY (467369) (NY), (888) 789-7777 or ccpg.org (CT), morethanagame.nc.gov (NC), 1800gambler.net (WV)

Indiana vs Ohio State Over/Under Analysis

The over/under is set at 52.5 in this game. Both defenses are excellent, and I expect a low-scoring, high-intensity ball game from start to finish. By low-scoring I am thinking mid to high 20s, I would leave the over/under bet alone, but if I had to bet it I would lean towards the over.

DraftKings

4.5/5

Tip: Bet over 52.5

• Indiana offense needs to be consistent
• Turnovers will be huge
• Indiana defense to play well

Bet $5, Get $200 + 3 Months of NBA League Pass

Get bonus now

Prediction:

Take the Hoosiers and the points, and don’t be surprised if the Hoosiers keep this close to the end.

Indiana +12.5