Seen on:
as known from New York Timesas known from USA Todayas known from yahoo!
VA
The Grueling Truth - Where Legends Speak / Latest College Football News & Rumors / College Football Week 4 Preview and Predictions

College Football Week 4 Preview and Predictions: Clemson/Wake Forest, Ark/Tex A&M, Tenn/Fla, USC/Oregon State and more

Publish Date: 09/23/2022
Fact checked by: Mike Goodpaster
CLEMSON, SOUTH CAROLINA - SEPTEMBER 17: DJ Uiagalelei #5 of the Clemson Tigers scrambles Lduring their game at Memorial Stadium on September 17, 2022 in Clemson, South Carolina. (Photo by Grant Halverson/Getty Images)

College Football Week 4 Predictions

Week 3 saw Kansas, Oregon, Washington, & Penn State all making big statements, along with several barnburner-type contests headlined by App State’s Hail Mary victory. Week 4 has three ranked versus ranked matchups but also features many games flying under the radar with some interesting point spreads. Check out the top football betting strategies.

Check out the top sportsbooks for betting on College Football

DraftKings
4.6/5
DraftKings Review
New Customers: Bet $5+ and get $300 in Bonus Bets if it wins!
Bet now
GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-522-4700, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD). 21+ and present in most states. (18+ DC/KY/NH/WY). Void in ONT/OR/NH. Eligibility restrictions apply. On behalf of Boot Hill Casino & Resort (KS). Pass-thru of per wager tax may apply in IL. 1 per new customer. Must register new account to receive reward Token. Must select Token BEFORE placing min. $5 bet to receive $300 in Bonus Bets if your bet wins. Min. -500 odds req. Token and Bonus Bets are single-use and non-withdrawable. Bet must settle by and Token expires 2/22/26. Bonus Bets expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 2/15/26 at 11:59 PM ET. Sponsored by DK.
FanDuel
4.6/5
FanDuel Review
Bet & Get up to $1,000 in Bonus Bets!
Bet now
Gambling Problem? Call 1-800-GAMBLER or visit RG-help.com. Call 1-888-789-7777 or visit ccpg.org/chat (CT). Hope is here. Visit www.helpmygamblingproblem.org (MA). Play it Safe. Call 1-800-547-6133 or visit mdgamblinghelp.org (MD). Call 1-855-860-2942 or visit gamblinghelplineonline.org (WV). 21+ (18+ DC, KY, MD and restricted states for KS). An affiliation with Kansas Star Casino. First online real money wager only. $5 free deposit credited. Bonus credited upon wager of $5 or more within 72 days after receipt. Restrictions apply. See terms at sportsbook.fanduel.com.
BetMGM
4.5/5
BetMGM Review
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Bet now
Gambling problem? Call 1-800-GAMBLER (Available in the US) Call 877-8-HOPENY or text HOPENY (467369) (NY) Call 1-800-327-5050 (MA) 21+ only. Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). Rewards are non-withdrawable bonus bets that expire in 7 days. In partnership with Kansas Crossing Casino and Hotel. See BetMGM.com for Terms. US promotional offers not available in DC, Mississippi, New York, Nevada, Ontario, or Puerto Rico.

Marquee Matchups

#5 Clemson vs #21 Wake Forest: We know the Tiger defense will travel fine but can QB DJ Uiagalelei and company put up points? Wake Forest almost got caught looking ahead, narrowly defeating a good Liberty program 37-36. Demon Deacons QB Sam Harford cannot be reckless with the ball this week facing a defense that is very stout. Liberty QB Kaidon Salter hurt Wake Forest thru the air and on the ground so it will be intriguing to see if DJ can do some of that. Clemson winning is my official prediction but the touchdown line had me wondering all week if the Tigers could cover on the road.

The Pick: Clemson -7 

 

#10 Arkansas vs #23 Texas A&M: The Aggies were able to hold off Miami after losing to App State in Week 2 but now face a stern test against the Razorbacks. Arkansas is a rising program no doubt but key injuries especially on defense has that side of the ball getting gashed. In fact, the Hogs were down 17-0 early and trailed 27-17 until Arkansas was able to kick in high gear winning 38-27 over Missouri State. A&M started a different quarterback but it really didn’t do a whole lot beyond getting them a win. Miami had numerous opportunities but failed to take advantage. Twice Arkansas covered the spread when I picked them, but all these injuries have me skittish.

The Pick: Aggies -2

 

Under The Radar

 

#11 Tennessee vs #20 Florida: Everything seems to be pointing to a Vols victory in this rivalry game. The funny thing is the Gators have a current 5-game winning streak in the series. Tennessee’s defense isn’t great by any means, but they can sure light up the scoreboard averaging 52 points per game early in the season. The Gators got a big win over then highly-ranked Utah but turned right around and lost to Kentucky, getting shut out in the 2nd half in the Swamp. The hype after the Utah performance from QB Anthony Richardson has fallen dramatically, and for a good reason. Richardson has 4 interceptions and just 28 yards rushing combined in the last two weeks. All that said, this College Football junkie thinks Tennessee will win however, that 11-point opening spread seemed a little too wide.

The Pick: Florida +10.5

Bet on Florida/Tennessee

Spread Moneyline Total
Bet Spread with Caesars +315 Odds From Fanduel Over 62.5 Odds from Betmgm
See Bet365 Odds -410 Odds from DraftKings See Odds from Caesars

 

#7 USC vs. Oregon State: The Trojans offense is chugging right along, which given the new coaching hire and elite players transferred in is really no surprise. The Beavers had a productive season last year and, now sitting at 3-0 managed to carry that good mojo from 2021. Speaking of 2021, Oregon State beat USC 45-27, and the Beavers have been a tough out playing at home in Corvallis.

The Pick: USC -6 

 

Saturday Upset Special

Minor upset from Notre Dame as a slight dog +1.5 at UNC. Check out the top football betting sites.

 

Hardcore Barnburners

 

#17 Baylor vs Iowa State: This important September matchup in the Big-12 should live up to the close point spread. This is a key spot for both teams if they want to compete for a conference title. Iowa State got a nice win over their in-state rival Hawkeyes and now gets home-field advantage. Baylor will need to cut down on the Bears’ penalties at BYU. The under is a pretty good bet by the way.

The Pick: Baylor +2.5 The Bears kick a late field goal to win. 

 

Minnesota vs Michigan State: The Spartans had a horrible start at Washington, down 29-8 at the half but did claw their way back to an extent anyways. The Gophers opened as a -2.5 and have looked the part of a team that should have a chance to win this one deep in the fourth quarter. Passing is the major weakness for the MSU defense so Minnesota will have to find a way to make explosive plays which just got harder losing their #1 option at WR Chris Altman-Bell for the season. Something tells me Sparty will bounce back at home.

The Pick: Michigan State +3

 

Against The Spread

 

Florida +10.5 covers against Tennessee.

 

Hawaii +4.5 covers versus NMST.

 

Quick Hits Recap

 

-Washington QB Michael Penix Jr. threw for almost 400 yards and 4 TD’s in a convincing victory by the Huskies over Michigan State 39-28.

 

-Texas stud RB Bijan Robinson rushed for 183 yards on 20 carries scoring 3 touchdowns in a 41-20 win over UTSA.

 

-The Trojans tandem of Austin Jones and Travis Dye produced 212 rushing yards and 2 TD’s combined in a 45-17 rout of Fresno State.

 

-Kansas is now 3-0, the last time they scored 159 points thru 3 games the Jayhawks went 12-1 in 2007.

 

-Minnesota RB Mo Ibrahim broke a school record of 200+ rushing yards in a game for the 4th time in his career. He also tied Daryl Thompson for career rushing TD’s.

 

-App State’s 53-yard Hail Mary victory touchdown over Troy 32-28 was absolutely insane.  On the Mountaineers previous possession App State turned the ball over on downs after driving the field for almost 9 minutes on 17 plays.

 

Written by Chris Carlson Host of The College Ball Show Podcast available at blogtalkradio.com/ropeadoperadio & Follow on Twitter @RopeADopeRadio

Read Also
Top 10 Greatest USC vs. Notre Dame Football Games of All Time
Few rivalries in sports capture the pageantry, tradition, and sheer drama of ...
Top 10 Penn State Football Players of All Time: Who is the Greatest Nittany Lion?
Penn State is one of the most iconic names in College Football ...
Bet365 Promo
NCAA Football Week 12: Betting All Top 25 Games against the Spread
Point Spread: Texas -13.5 Moneyline Texas -610 Moneyline Arkansas +440 Over/Under 56.5 ...
NCAA Football Week 7: Betting All Top 25 Games against the Spread
week one Against the spread: 8-8 Week Two Against the Spread 9-7 ...
NCAA Football Week 6: Betting All Top 25 Games against the Spread
week one Against the spread: 8-8 Week Two Against the Spread 9-7 ...
NCAA Football Week 5: Betting All Top 25 Teams against the spread
week one Against the spread: 8-8 Week Two Against the Spread 9-7 ...
NCAA Football Week 4: Betting All Top 25 Teams against the spread
week one Against the spread: 8-8 Week Two Against the Spread 9-7 ...
Esteban de Jesus, Roberto Duran y AIDS (1972-89)
Many of us dream of celebrity sports fame, but only cruel individuals ...
Indiana Basketball Weekly
Welcome to Indiana Basketball Weekly, your dedicated podcast for all things Indiana ...
Top Betting Sites
Top Betting Bonuses
DraftKings
DraftKings
DraftKings Review
4.6/5
FanDuel
4.6/5
BetMGM
4.5/5
Bet365
4.5/5
Caesars
4.5/5
Fanatics
Fanatics
Fanatics Review
4.3/5
Barstool
Barstool Review
4.5/5
Bally Bet
Bally Bet Review
4.3/5
DraftKings
DraftKings Promo
New Customers: Bet $5+ and get $300 in Bonus Bets if it wins!
T&Cs apply
4.6/5
GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-522-4700, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD). 21+ and present in most states. (18+ DC/KY/NH/WY). Void in ONT/OR/NH. Eligibility restrictions apply. On behalf of Boot Hill Casino & Resort (KS). Pass-thru of per wager tax may apply in IL. 1 per new customer. Must register new account to receive reward Token. Must select Token BEFORE placing min. $5 bet to receive $300 in Bonus Bets if your bet wins. Min. -500 odds req. Token and Bonus Bets are single-use and non-withdrawable. Bet must settle by and Token expires 2/22/26. Bonus Bets expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 2/15/26 at 11:59 PM ET. Sponsored by DK.
FanDuel
FanDuel Promo
Bet & Get up to $1,000 in Bonus Bets!
T&Cs apply
4.6/5
Gambling Problem? Call 1-800-GAMBLER or visit RG-help.com. Call 1-888-789-7777 or visit ccpg.org/chat (CT). Hope is here. Visit www.helpmygamblingproblem.org (MA). Play it Safe. Call 1-800-547-6133 or visit mdgamblinghelp.org (MD). Call 1-855-860-2942 or visit gamblinghelplineonline.org (WV). 21+ (18+ DC, KY, MD and restricted states for KS). An affiliation with Kansas Star Casino. First online real money wager only. $5 free deposit credited. Bonus credited upon wager of $5 or more within 72 days after receipt. Restrictions apply. See terms at sportsbook.fanduel.com.
BetMGM
BetMGM Promo
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
T&Cs apply
4.5/5
Gambling problem? Call 1-800-GAMBLER (Available in the US) Call 877-8-HOPENY or text HOPENY (467369) (NY) Call 1-800-327-5050 (MA) 21+ only. Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). Rewards are non-withdrawable bonus bets that expire in 7 days. In partnership with Kansas Crossing Casino and Hotel. See BetMGM.com for Terms. US promotional offers not available in DC, Mississippi, New York, Nevada, Ontario, or Puerto Rico.
Bet365
Bet365 Promo
Bet $5 & Get $150 in Bonus Bets Win or Lose
T&Cs apply
4.5/5
Whatever the moment. It's Never Ordinary at bet365. That's why if you sign up now you will receive $150 in Bonus Bets Win or Lose when you bet $5! Minimum $10 deposit required. Minimum odds -500 or greater. Bonus Bets wager excluded from returns. New customers only. T&CS, time limits and exclusions apply.GAMBLING PROBLEM? CALL OR TEXT 1-800-GAMBLER (AZ/CO/IL/IN/KS/KY/LA/MD/NC/NJ/OH/PA/TN/VA) or 1-800-BETS OFF (IA). 21+ (18+ KY). Must be present in AZ/CO/IA/IL/IN/KS/KY/LA (select parishes)/MD/NC/NJ/OH/PA/TN/VA.
Caesars
Caesars Promo
Up to $250 Bonus Bet
T&Cs apply
4.5/5
21+ New users only. Must register using eligible promo code. First bet after registration must qualify. Max. Bonus Bet: $1,000. Bonus Bet expires 14 days after receipt. Void where prohibited. See Caesars.com/promos for full terms. Gambling Problem? 1-800-GAMBLER (1-800-426-2537)
Fanatics
Fanatics Promo
Bet $50, Get $300 in FanCash
T&Cs apply
4.3/5
Must be 21+. GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-522-4700, Home (MD), (800)-327-5050 or MA Gambling Helpline (MA), Call (877)8-HOPENY or text HOPENY (467369) (NY), or Call 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), (888) 789-7777 or CONNECTICUT COUNCIL – ON PROBLEM GAMBLING (CT), or 1-800-9-WITH-IT (IN), If gambling is more than a game, free help is available . . . - NCDHHS Problem Gambling (NC). New customers in AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA, MA, MD, MI, MO, NC, NJ, NY, OH, PA, TN, VA, VT, WV, or WY. Must opt-in and wager $10+ cash on any market with odds of -500 or longer to receive $100 in FanCash each day for your first 3 days (issued when qualifying wager settles). Your 3 days begin the day you establish your account. FanCash rewards expire at 11:59 p.m. ET 7 days from issuance. Terms, including FanCash terms, apply - see Fanatics Sportsbook app.
Barstool Promo
T&Cs apply
4.5/5
Latest Sport News
2026 Houston Gamblers Season Preview: A Rebrand and a Reset
The 2026 UFL season marks another identity shift ...
The Complexities of Bob Knight: The Greatest Coach of All-Time?
  Bob Knight, born in 1940 and raised ...
Top 11 Dynasties in NFL History
What does the word “dynasty” mean to you? ...
NFL: Super Bowl MVPs- Are Kickers Left Out in the Cold?  
Super Bowl LX was a battle with few ...
Top-10 Closers in MLB History
Dominance in the ninth inning is different. It’s ...
2026 Ruffles NBA All-Star Celebrity Game Preview
Date: Friday, February 13, 2026 Time: 7:00 PM ...
Top-10 Indiana High School Basketball Teams of All-Time
Few traditions in sports capture the heart of ...
2026 Columbus Aviators: Mapping the Flight Plan Under Ted Ginn Jr
The 2026 UFL season brings one of the ...
Top 10 Heavyweight Boxing Upsets of All Time: Which Upset was the Most Shocking?
What's more exciting than the heavyweight Champion of ...
Latest NFL Betting Picks

Our Team
Mike GoodpasterMark LewisAuthor IconJohn RaspantiSamuel Teets
+6
Mike Goodpaster
Mike Goodpaster
Chief Editor
Mark Lewis
Mark Lewis
Editor
Author Icon
Christopher Carlson
Author
John Raspanti
John Raspanti
Author
Samuel Teets
Samuel Teets
US Sports Veteran
Daniel Kornhauser
Daniel Kornhauser
Author
Chris Benedict
Chris Benedict
Editor
James Ernest
James Ernest
Author
Shelley Harcar
Shelley Harcar
Sports Writer
Ellis Williams
Ellis Williams
Author
Dr. Jay Gee
Dr. Jay Gee
Author

21+ and present in VA. Gambling Problem? Call 1-800-GAMBLER.

This site is using Cloudflare and adheres to the Google Safe Browsing Program. We adapted Google's Privacy Guidelines to keep your data safe at all times.
Virginia Town HallCloudflareSSL
Close
Our Sports Pros recommend these awesome sports betting sites this week:
DraftKings
DraftKings Promo
New Customers: Bet $5+ and get $300 in Bonus Bets if it wins!
Our Favorite
T&Cs and 21+ apply
Code:
Open DraftKings
Get Bonus
FanDuel
FanDuel Promo
Bet & Get up to $1,000 in Bonus Bets!
Best Slots
T&Cs and 21+ apply
Code:
Open FanDuel
Get Bonus
BetMGM
BetMGM Promo
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Newcomer
T&Cs and 21+ apply
Code:
Open BetMGM
Get Bonus
×
Your Promo Code:
The bonus offer of was already opened in an additional window. If not, you can open it also by clicking the following link:
Play now