Seen on:
as known from New York Timesas known from USA Todayas known from yahoo!
OH
The Grueling Truth - Where Legends Speak / Latest College Football News, Picks and Betting Predictions / College football week 4 picks, predictions against the spread for all Top 25 games

College football week 4 picks, predictions against the spread for all Top 25 games

Publish Date: 09/22/2022
Fact checked by: Mark Lewis
MADISON, WI - SEPTEMBER 17: Wisconsin Badgers offensive lineman Tanor Bortolini (63) lifts up Wisconsin Badgers running back Braelon Allen (0) after a touchdown in celebration durning a college football game between the New Mexico State Aggies and the Wisconsin Badgers on September 17th, 2022 at Barry Alvarez field in Camp Randall Stadium in Madison, WI. (Photo by Dan Sanger/Icon Sportswire via Getty Images)

Week 4 top 25 picks

Last week was our first week picking all the top 25 games against the spread, and we went 13-6! Check out the top football betting strategies I use for betting on college football.

Maryland at No. 4 Michigan (-17) (12 p.m., FOX)

Maryland is explosive on offense, but let’s face it, they have faced nobody the caliber of Michigan yet. That said, Michigan has not faced any team the caliber of Maryland yet.

The Wolverines look strong on defense again, and JJ McCarthy is the real deal at Quarterback. The Terps have a tendency to look good until they get to big ten play and I think that will happen again.

Pick: Michigans 41  Maryland 26(Take Maryland +17)

Check out the top sportsbooks for betting on college football

FanDuel
4.6/5
FanDuel Review
New Users – Get $350 in Bonus Bets when you wager $5 for 7 days
Bet now
Gambling Problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Call 1-888-789-7777 or visit ccpg.org/chat (CT). Hope is here. GamblingHelpLineMA.org or call (800) 327-5050 for 24/7 support (MA). Visit www.mdgamblinghelp.org (MD). Call 1-877-8HOPE-NY or text HOPENY (467369) (NY). 21+ (18+ D.C., KY, WY) and present in select states (for KS, in affiliation with Kansas Star Casino). First online real money wager only. Min $5 wager required for 7 consecutive days.$5 first deposit required. Bonus issued as nonwithdrawable bonus bets which expire 7 days after receipt. Restrictions apply. See terms at sportsbook.fanduel.com. Call 1-877-770-7867 (LA). ™/© 2026 MLB
BetMGM
4.5/5
BetMGM Review
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Bet now
Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.
DraftKings
4.5/5
DraftKings Review
New DraftKings Customer: SPEND $5, GET $200 IN BONUSES
Bet now
To be eligible for DraftKings Sportsbook and the Promotion, you must be physically located in AR, AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA (select parishes), MA, MD, ME, MI, MO, NC, NJ, NH, NY, OH, OR, PA, PR (residents only), TN, VA, VT, WY, WV, CA-ONT or CA-AB (each an “Eligible Jurisdiction” or, collectively, the “Eligible Jurisdictions”). Must be 21+ years of age or older (18+ if in DC/NH/PR/WY/CA-AB) (19+ in CA-ONT). GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA) Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/NH/PR/WY). Void in CAN. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new DraftKings customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets. Stake removed from payout. Reward issued as $50 in Bonus Bets every 7 days via click-to-claim for 21 days. Bonus Bets and click-to-claims expire 7 days (168hrs) after issuance. Terms: Promos | DraftKings Sportsbook . Ends 9/20/26 at 11:59 PM ET. Sponsored by DK.

No. 5 Clemson (-7) at No. 21 Wake Forest (12 p.m., ABC)

Jump on this game before the value increases, which it will during the week. Clemson’s defence is the real deal, and the offense is hit-and-miss, while Wake Forest scores a lot of points. The Demon Deacons will score some but not enough.

Pick: Clemson 27  Wake Forest 24(Take Wake and the 7 points)

 

No. 17 Baylor at Iowa State (-1.5) (12 p.m., ESPNU/ESPN2)

This game looks like a toss-up, and both teams need this win. History favors the home team in this one, and history also favors a close game. I have a feeling Baylor gets this one.

Pick: Baylor 27  Iowa State 24(Take Baylor and the 1.5 points)

 

Kent State at No. 1 Georgia (-44.5) (12 p.m., ESPN+)

Kent State has lost by an average 0f 27 points to Washington and Oklahoma. The only question is how seriously the Bulldogs will take this game. It’s hard to see Kent State scoring many points in this game.

Pick: Georgia 51  Kent State 3(Take Georgia and give the 44.5 points)

 

Central Michigan at No. 14 Penn State (-26) (12 p.m., BTN) 

James Franklin in his last five matchups against MAC opponents, has won by an average 0f 40 points, which will continue here. I am worried about a possible back door cover here, though.

Pick: Penn State 45  Central Michigan 17(Take the Lions and give the 26 points)

 

Middle Tennessee State at No. 25 Miami (-26) (3:30 p.m, ACC Network) 

Lets make this easy, MTSU lost their opener 42-7 against James Madison, and the Canes are coming off a tough loss; take the Canes. Check out the top football odds.

Pick: Miami 37  MTSU 20( Take the Blue Raiders and the the 26 points)

 

No. 20 Florida at No. 11 Tennessee (-9.5) (3:30 p.m., CBS) 

You never know what you’ll get with gators QB Anthony Richardson and I expect him to struggle at Neyland stadium. Tennessee has been explosive on offense and they have a score to settle with the Gators.

Pick: Tennessee 34  Tennessee 24(Take the Vols and give the 9.5 points)

Bet on Tennessee/Florida

No. 21 Texas (-4.5) at Texas Tech (3:30 p.m, TBD)

A lot of value here betting on the Longhorns as Texas tech last beat Texas at home in 08. That streak continues in this one.

Pick: Texas 38, Texas Tech 57(Take the Raiders and the points)

 

Tulsa vs No. 16 Ole Miss (-20.5) (4 p.m., SEC Network) 

Tulsa is a good team, but the Rebels are averaging over 270 yards on the ground per game and will bully Tulsa in this one.

Pick: Ole Miss 41  Tulsa 16(Take Ole Miss and give the 20.5 points)

 

No. 15 Oregon (-6.5) at Washington State (4 p.m., FOX) 

Oregon got a huge win over BYU last weekend, but Washington State has been a big surprise this season, and 6.5 points are enough to make me take the Cougars.

Pick: Oregon 27  Washington State 24(Take the Cougars and the 6.5 points)

 

Northern Illinois at No. 8 Kentucky (-25.5) (7 p.m., ESPN2)

The Wildcats defense has been stellar, but Northern Illinois is a good team that should not be overlooked. The Wildcats win, but it won’t be easy.

Pick: Kentucky 31  Northern Illinois 17( Take the Huskies and the 25.5 points)

 

No. 10 Arkansas at No. 23 Texas A&M (-2.5) (7 p.m., ESPN)

Arkansas is the real deal with QB KJ Jefferson and stout run defense and they will win this game.

Pick: Arkansas 30  Texas A&M 23(Take the Hogs and the 2.5 points)

 

Wisconsin at No. 3 Ohio State (-18) (7:30 p.m., ABC) 

Tough one to pick with the points because the badgers can run and pass this season, and the Buckeyes’ defense has not been tested yet.

Pick: Ohio State 48  Wisconsin 13(Take the Buckeyes and give 18 points)

Bet on Wisconsin/Ohio State

Vanderbilt at No. 2 Alabama (-40.5) (7:30 p.m., SEC Network)

This is simple, isn’t it? Bama by as many points as Bama wants to win.

Pick: Alabama 55  Vanderbilt 7(Take Bama and give the 40.5 points)

 

Kansas State at No.6 Oklahoma (-13) (8 p.m., FOX) 

Kansas State has played Oklahoma tough as of late, but the Sooners with Venables seem different. Check out the top football betting sites.

Pick: Oklahoma Sooners 42  Kansas State 24(take the Sooners and give the 13 points)

 

No. 7 USC (-6.5) at Oregon State (9:30 p.m., Pac-12 Network) 

There should be fireworks in this matchup as USC averages over 50 points per game, and Oregon State is not too shabby at a little over 45 points per game.

Pick: USC 44  Oregon State 34(Take Trojans and give the 6.5 points)

 

Wyoming at No. 19 BYU (-21) (10:15 p.m., TBD)

Wyoming’s last win in Provo was in 1987, and it’s not happening this year. BYU had a disastrous loss at Oregon and needs to bounce back in this one.

Pick: BYU 34  Wyoming 17(Take the Cowboys and the 21 points)

Check out the top Sportsbook providers for betting on College Football

FanDuel
1.
4.6/5
New Users – Get $350 in Bonus Bets when you wager $5 for 7 days
USA
USA Players Welcome
PayPal
Bank Transfer
Cheque
Ohio Casino Control Commission (OCCC)
Bet now
Gambling Problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Call 1-888-789-7777 or visit ccpg.org/chat (CT). Hope is here. GamblingHelpLineMA.org or call (800) 327-5050 for 24/7 support (MA). Visit www.mdgamblinghelp.org (MD). Call 1-877-8HOPE-NY or text HOPENY (467369) (NY). 21+ (18+ D.C., KY, WY) and present in select states (for KS, in affiliation with Kansas Star Casino). First online real money wager only. Min $5 wager required for 7 consecutive days.$5 first deposit required. Bonus issued as nonwithdrawable bonus bets which expire 7 days after receipt. Restrictions apply. See terms at sportsbook.fanduel.com. Call 1-877-770-7867 (LA). ™/© 2026 MLB
BetMGM
2.
4.5/5
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
USA
USA Players Welcome
PayPal
Bank Transfer
VIP Preferred
Ohio Casino Control Commission (OCCC)
Bet now
Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.
DraftKings
3.
4.5/5
New DraftKings Customer: SPEND $5, GET $200 IN BONUSES
USA
USA Players Welcome
PayPal
VIP Preferred
Play+
Ohio Casino Control Commission (OCCC)
Bet now
To be eligible for DraftKings Sportsbook and the Promotion, you must be physically located in AR, AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA (select parishes), MA, MD, ME, MI, MO, NC, NJ, NH, NY, OH, OR, PA, PR (residents only), TN, VA, VT, WY, WV, CA-ONT or CA-AB (each an “Eligible Jurisdiction” or, collectively, the “Eligible Jurisdictions”). Must be 21+ years of age or older (18+ if in DC/NH/PR/WY/CA-AB) (19+ in CA-ONT). GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA) Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/NH/PR/WY). Void in CAN. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new DraftKings customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets. Stake removed from payout. Reward issued as $50 in Bonus Bets every 7 days via click-to-claim for 21 days. Bonus Bets and click-to-claims expire 7 days (168hrs) after issuance. Terms: Promos | DraftKings Sportsbook . Ends 9/20/26 at 11:59 PM ET. Sponsored by DK.
Fanatics
4.
4.2/5
10 x $100 bet match in FanCash
USA
USA Players Welcome
Venmo
PayPal
Apple Pay
Ohio Casino Control Commission (OCCC)
Bet now
Must be 21+. GAMBLING PROBLEM? CALL 1-800-GAMBLER OR CALL 1-800-MY-RESET, www.mdgamblinghelp.org (MD), (800)-327-5050 or gamblinghelplinema.org (MA), Call (877)8-HOPENY or text HOPENY (467369) (NY), (888) 789-7777 or ccpg.org (CT), morethanagame.nc.gov (NC), 1800gambler.net (WV)
Caesars
5.
Bet $1 and get double the winnings up to $25 for your next 10 bets
USA
USA Players Welcome
PayPal
Bank Transfer
E-Check
Ohio Casino Control Commission (OCCC)
Best Alternative
FanDuel Open FanDuel
21+ New users only. Must register using eligible promo code. First bet after registration must qualify. Max. Bonus Bet: $1,000. Bonus Bet expires 14 days after receipt. Void where prohibited. See Caesars.com/promos for full terms. Gambling Problem? 1-800-GAMBLER (1-800-426-2537)

 

No. 13 Utah (-15) at Arizona State (10:30 p.m., TBD)

Arizona State is in disarray as the bottom has fallen out, and Herm Edwards has been fired. The Utes are the better team and have played much better since an opening season loss at Florida.

Pick: Utah 38  Arizona State 20(Take the Utes and give the 15 points)

 

Stanford at No. 18 Washington (-12) (10:30 p.m., FS1) 

Michael Pennix has played well for the Huskies and last week’s win over Michigan State was big. The Huskies will roll in this one, also.

Pick: Washington 37  Stanford 20(Take the Huskies and give the 12 points)

Read Also
College Football Rivalry Week Predictions: OSU/Mich, Tex/Tex A&M, So.Car/Clem, and More
Week 13 gave us thrilling upsets, with three two-loss SEC teams losing ...
NCAA Football Week 12: Betting All Top 25 Games against the Spread
Point Spread: Texas -13.5 Moneyline Texas -610 Moneyline Arkansas +440 Over/Under 56.5 ...
BetMGM Promo
NCAA Football Week 11: Betting All Top 25 Games against the Spread
week one Against the spread: 8-8 Week Two Against the Spread 9-7 ...
NCAA Football Week 10: Betting All Top 25 Games against the Spread
week one Against the spread: 8-8 Week Two Against the Spread 9-7 ...
NCAA Football Week 9: Betting All Top 25 Games against the Spread
week one Against the spread: 8-8 Week Two Against the Spread 9-7 ...
NCAA Football Week 8: Betting All Top 25 Games against the Spread
week one Against the spread: 8-8 Week Two Against the Spread 9-7 ...
College Football Week 7 Predictions: OSU/Oregon, OKL/Tex, Penn.St/USC, Ole Miss/LSU and More
In week 6, all hell broke loose with Vandy in a complete ...
NCAA Football Week 7: Betting All Top 25 Games against the Spread
week one Against the spread: 8-8 Week Two Against the Spread 9-7 ...
NCAA Football Week 6: Betting All Top 25 Games against the Spread
week one Against the spread: 8-8 Week Two Against the Spread 9-7 ...
NCAA Football Week 5: Betting All Top 25 Teams against the spread
week one Against the spread: 8-8 Week Two Against the Spread 9-7 ...
NCAA Football Week 4: Betting All Top 25 Teams against the spread
week one Against the spread: 8-8 Week Two Against the Spread 9-7 ...
NCAA Football Week 3: Betting All Top 25 Teams against the spread
Week 1 ATS: 6-6 Week 2 ATS: 12-7 Overall 18-13 Point Spread: ...
College Football Week 2 Predictions: Tex-Mich, Colo-Neb, Kan-Ill, Ga Tech-Syr and more
Week 1 saw dominant outings from Georgia, Penn St, and Miami, along ...
Top Betting Sites
Top Betting Bonuses
Latest Sport News
Top 15 Indiana High School Basketball Players of the 1960s
The 1960s marked one of the most competitive ...
Top 20 Indiana High School Basketball Players of the 1980s
The 1980s were one of the most talent-rich ...
North Dakota State Must Prove Its Dynasty Works Every Week
College football likes to say you have to ...
Moses Itauma vs Filip Hrgovic: Heavyweight Collison 
Filip Hrgovic represents a step on the heavyweight ...
Cal Poly Opens Tim Skipper’s Era on John Madden Night
Before Tim Skipper reaches halftime of his first ...
Hawai’i at Stanford 2026 Preview: Prediction, Betting Odds & 4 Prop...
Saturday, August 29, 2026 Time: 7:00 PM ET ...
Our Team
Mike GoodpasterJames ErnestMark LewisAuthor IconJohn Raspanti
+8
Mike Goodpaster
Mike Goodpaster
Chief Editor
James Ernest
James Ernest
Author
Mark Lewis
Mark Lewis
Editor
Author Icon
Christopher Carlson
Author
John Raspanti
John Raspanti
Author
Samuel Teets
Samuel Teets
US Sports Veteran
Daniel Kornhauser
Daniel Kornhauser
Author
Marvin Uzor
Marvin Uzor
Author
Ellis Williams
Ellis Williams
Author
Chris Benedict
Chris Benedict
Editor
Shelley Harcar
Shelley Harcar
Sports Writer
Dr. Jay Gee
Dr. Jay Gee
Author
LaMarr Fields
LaMarr Fields
Author

21+ and present in OH. Gambling Problem? Call 1-800-GAMBLER.

This site is using Cloudflare and adheres to the Google Safe Browsing Program. We adapted Google's Privacy Guidelines to keep your data safe at all times.
CloudflareSSL
×
Your Promo Code:
The bonus offer of was already opened in an additional window. If not, you can open it also by clicking the following link:
Play now