NCAA Tournament Regional Semi-Final: Purdue Boilermakers vs Houston Cougars 03-28-25

The Houston Cougars and Purdue Boilermakers rolled through the first two rounds of this tournament with relative ease, and now these two titans will collide to see who advances to the Elite Eight.

Purdue Boilermakers vs Houston Cougars

• Point Spread: Houston -8.5
• Moneyline Purdue +285
• Moneyline Houston -365
• Over/Under 131.5

Purdue successfully defeated High Point and McNeese in the first two rounds of the tournament. However, they face a much tougher challenge now against a veteran Cougars team that has significant experience in high-stakes games. Houston leads the nation in scoring defense and is also the top team in perimeter shooting on the offensive end. This year’s Purdue team is different from previous years; while Kaufman-Renn provides a solid low post presence, he won’t have the easy looks he enjoyed in the earlier rounds. Houston is known for turning games into a grind, and they will likely overwhelm Purdue, securing their spot in the Elite Eight.

Purdue vs Houston Moneyline

The moneyline value exists for a MoneyLine bet on MPurdue if you think they can pull off the upset. The safe bet is to take Houston and give the points.To find the best line, you need accounts with multiple sportsbooks, and we got you covered as we break down the best sports betting app

DraftKings

4.5/5

Tip: Bet Houston -8.5

• Cougars defense controls this game
• Rebounding will be crucial
• Neutral site

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Purdue vs Houston Over/Under Analysis

The line is 131.5 and I will bet the over, I expect this to be a low scoring game but I think these teams are good enough to push into the high 60s.

DraftKings

4.5/5

Tip: Bet the Over 131.5

• Braden Smith needs a big night
• turnovers will be key
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Prediction

Can Purdue hold up against a vicious Houston defense? I think they will for a half and then Purdue will get shutdown as the big three for the Boilers will get tired. The Cougars are deeper and that will be the difference in this game. Houston 68  Purdue 57

Bet Houston -8.5