As the Sweet 16 continues on Friday night, the South Region heads to Dallas, Texas, for its regional semi-final. The Houston Cougars face the Duke Blue Devils in the matchup, which should be one of the weekend’s top games. The Blue Devils defeated James Madison in Round 2, while the Cougars edged past Texas A&M in an overtime thriller that brought them here. Tip-off time on Friday is set for 9:30 PM EST.
Houston is a solid favorite, but Duke played their best game of the year in a blowout win over James Madison, and Houston has not played well as of late.
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- Point Spread: Houston -4.5
- Moneyline Duke +160
- Moneyline Houston -194
- Over/Under 133.5
These odds were updated at 9 am EST on 03/28/24, coming from Draft Kings.
Our Best Pick: Duke to Cover
I expect the Cougars to rebound quickly against Duke on Friday after suffering a scare in their opener on Sunday night. Their physical brand of basketball should present problems for Duke’s guards, who should find this challenge more than sufficient. McCain has had an outstanding tournament thus far but will now face off against a Houston backcourt which successfully held Texas A&M All-American guard Wade Taylor IV to just 5-of-26 shooting from the field.
Houston’s backcourt scored 41 points against Texas A&M, providing McCain and Roach a formidable physical test. Houston has outscored their opponents in the paint by 12 points this tournament. Duke averaged 37.5 rebounds in their two wins but aren’t as consistent in grabbing offensive and defensive boards as was done by Texas A&M against Houston, which will prove problematic as Houston attacks the glass from all five positions, especially on offense.
Come Friday night, the Cougars enter this game shooting over 55% from the floor and scoring more points than they have all season. On defense, they are holding opponents to just 29% from 3-point range – an astounding feat considering they ranked first overall in field goal defense before this tournament began.
Houston is the better team and they might win the game but I see value in betting Duke +4.5 points.
- Houston is a great defensive team
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Duke has been hot as of late
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Houston has not played well as of late
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Duke vs Houston Moneyline
To me, a money-line bet only makes sense on Duke, as I think they have a very real chance to pull off the upset in this game. Houston has struggled at times as of late and Duke has been playing lights out on both ends of the floor.
The Blue Devils are a live dog in this game, and if Houston is inconsistent at all over the 40 minutes, the Blue Devils have the weapons to pull off the upset and send the Cougars home earlier than expected.
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Duke has been hot
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Houston must control the Boards
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Cougars need to be consistent on offense
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Duke vs Houston Over/Under Analysis
The over/under looks about right. This game has all the earmarks of a game played in the 1960s, and given the way the Blue Devils have shot the ball lately, I am leaning towards betting the over in this game.
Duke and Houston can both score points quickly in a high scoring game and this game could hit the high 60s and go over the number,
- Rebounding will be key
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Both teams can be explosive on offense
- This game will be played in the high 60s/low 70s
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Duke vs Houston Spread Analysis
The Over/Under is spot on, Houston should be the favorite when looking back on the totality of the season. This Duke teame looked different against James Madison, they looked like Duke. Can they continue to play at that high level? They will have to if they want to win this game.
Houston needs to control the glass and grind down Duke. If they do that, they will win this game going away. If they don’t, they will have a big-time fight on their hands. Guard play, as always, will be big, and if Duke can hold their own on the boards, that will also elevate their chances to win this game.
- Guard play will be huge
- Duke needs to keep turnovers to a minimum
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Game will be played in the high 50s to Low 60s
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Duke vs Houston Player Props
McCain over 13.5 points
McCain scored thirty points in the Blue Devils’ blowout over James Madison. If he scores thirty points in this game, the Blue Devils will win again. I think the Cougars’ defense will look to shut McCain down, and while I do not think they will, he won’t get thirty points. I think he does score more than 13.5 points, though, in this one.
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Tip: Bet Micah Parrish 13.5 Ponts
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McCain scored 30 in JMU win
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McCain has been hot as of late
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GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/KY/NH/PR/WY). Void in NH/OR/ONT/PR. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new DraftKings Sportsbook customer. Must register new account to receive reward Token. Must select Token BEFORE placing min. $5 bet to receive $300 in Bonus Bets if your bet wins. Min. -500 odds req. Token and Bonus Bets are single-use and non-withdrawable. Bet must settle by and Token expires 5/3/26 at 11:59 PM ET. Bonus Bets expire in 7 days (168 hours). Stake removed from payout. Terms: Promos | DraftKings Sportsbook . Ends 4/26/26 at 11:59 PM ET.
Duke vs Houston Head to Head
This will be the first time the teams have played this season.
Injuries and Suspensions
Duke Blue Devils Injury Report
- J. Blakes- Quest
- J. Roach- Quest
- C. Foster- Out
Houston Cougars Injury Report
Conclusion
This will be an explosive game that could be a defensive battle or an offensive battle. I like Duke to hit enough shots to turn this into a tough game for the Houston Cougars. The Blue Devils have been inconsistent this season but seem to be hitting their stride. Houston was dominant for most of the season but, unlike Duke, have struggled some in this tournament. They overcame missing four key players because they fouled out before the overtime of their second-round win. I think taking the Debils and the points is the best bet in this game.
