NCAA Tournament Second Round Ole Miss Rebels vs Iowa State Cyclones-03-22-25

The No. 6 seed Rebels (23-11) will face the No. 3 seed Iowa State (25-9) in the second round of the NCAA tournament. Coach Chris Beard’s Rebels advanced by defeating No. 11 North Carolina in a game that shifted from being a blowout to a nail-biter. They managed to hold off the Tar Heels’ comeback, winning 71-64 on Friday. In contrast, Iowa State had a more straightforward path to the second round, dominating Lipscomb with a score of 82-55.

Ole Miss Rebels vs Iowa State Cyclones

• Point Spread: Iowa State -4.5
• Moneyline Ole Miss +164
• Moneyline Iowa State -200
• Over/Under 145.5

Iowa State forward Milan Momcilovic made his performance in the first round of the NCAA tournament against Lipscomb look effortless. He scored 20 points, shooting 8-for-14 from the field. Known for his physical presence around the rim, Momcilovic also presents a challenge for defenders with his ability to stretch the floor. Standing at 6 feet 8 inches and weighing 225 pounds, he can dribble and comfortably play as a guard on the wing. This season, Momcilovic has shot 41% from beyond the arc. Although Ole Miss features more size than Lipscomb, Momcilovic will still pose a significant challenge to even the most formidable defenses. Expect Ole Miss to defend against him with a combination of Malik Dia, Jaemyn Brakefield, and Dre Davis.

Ole Miss started four seniors and one junior in their game against North Carolina, and it’s likely that the same lineup will start on Friday. Their experience, both on and off the court, proved valuable when UNC began to close in on the Rebels’ 22-point lead. Thanks largely to senior point guard Sean Pedulla’s shooting, they were able to regain control and secure the victory.

Ole Miss vs Iowa State Moneyline

Moneyline value exists for a MoneyLine bet on Ole Miss if you think they can pull off the upset, and I think the best bet on either team is on the Cyclones and giving the points. To find the best line, you need accounts with multiple sportsbooks, and we got you covered as we break down the best sports betting app

DraftKings

4.6/5

Tip: Bet Iowa State -4.5

• Cyclones more balanced team
• Rebounding will be crucial
• Neutral site

New Customers: Bet $5+ Get $300 in Bonus Bets Instantly

Open DraftKings

The best NCAA betting sites

To satisfy the ever-growing market of NCAA bettors, the best basketball sportsbooks offer unique user experiences, huge payouts, and fantastic bonuses. Gamers no longer have to go to casinos to find some physical action. Online bookies let you play the game of risk from the comfort of your own home. We hope our guide can point you in the right direction so you can find the best gambling experiences on the internet.

Best Brand

DraftKings Promo

New Customers: Bet $5+ Get $300 in Bonus Bets Instantly

Get bonus now

GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/KY/NH/PR/WY). Void in NH/OR/ONT/PR. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new DraftKings Sportsbook customer. Must register new account to receive reward Token. Must select Token BEFORE placing min. $5 bet to receive $300 in Bonus Bets if your bet wins. Min. -500 odds req. Token and Bonus Bets are single-use and non-withdrawable. Bet must settle by and Token expires 5/3/26 at 11:59 PM ET. Bonus Bets expire in 7 days (168 hours). Stake removed from payout. Terms: Promos | DraftKings Sportsbook . Ends 4/26/26 at 11:59 PM ET.

Best Slots

FanDuel Promo

New Users – Bet $5 Get $250 If Your Bet Wins!

Get bonus now

Gambling Problem? Call 1-800-GAMBLER or visit RG Help . Call 1-888-789-7777 or visit Helpline and Chat – CONNECTICUT COUNCIL (CT). “Hope is here. GamblingHelpLineMA.org or call (800) 327-5050 for 24/7 support. 21+ and present in MA. Connect with a PlayWell Advisor at PlayWell.org. Visit Home (MD). Call 1-877-8HOPE-NY or text HOPENY (467369) (NY) 21+ (18+ D.C., KY, WY) and present in select states (for KS, in affiliation with Kansas Star Casino). First online real money wager only. $5 first deposit required. Bonus issued as nonwithdrawable bonus bets which expire 7 days after receipt. Restrictions apply. See terms at FanDuel Sportsbook

Newcomer

BetMGM Promo

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Get bonus now

Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) Call 877-8-HOPENY or text HOPENY (467369) (NY) Call 1-800-327-5050 (MA) 21+ only. Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). Rewards are non-withdrawable bonus bets that expire in 7 days. In partnership with Kansas Crossing Casino and Hotel. See BetMGM.com for Terms. US promotional offers not available in DC, Mississippi, New York, Nevada, Ontario, or Puerto Rico.

Award

Barstool Promo

–

T&Cs and 21+ apply

Ole Miss vs Iowa State Over/Under Analysis

The line is 145.5 and I will bet theunder as I think this is a rock fight of a game.

DraftKings

4.6/5

Tip: Bet the Over 145.5

• Both Teams solid on defense
• turnovers will be key
• Neutral site

New Customers: Bet $5+ Get $300 in Bonus Bets Instantly

Open DraftKings

These are two good teams that can make a deep run. I think that Iowa State is the better-balanced team and that will be the difference on this game. Iowa State 68  Ole Miss 60

Bet Iowa State -4.5