MLB St. Louis Cardinals vs Cincinnati-Reds: Odds, Tips and Predictions 04-28-25

Tonight, the St. Louis Cardinals (12–16) visit the Cincinnati Reds (15–13) at Great American Ball Park for the opener of a four-game series. First pitch is scheduled for 6:40 p.m. ET. The Reds are hot and the Cardinals are not headed into this series.

St. Louis Cardinals vs Cincinnati Reds

• Run Line: Cardinals -1.5
• Moneyline Cardinals -102
• Moneyline Reds -116
• Over/Under 9

These odds were updated at 9 am EST on 04/28/25, coming from DraftKings. Check out the top online MLB betting sites the only way to be great at sports betting is to have multiple accounts with at least three sportsbooks to get the best odds for every game.

Key Matchup Notes

• Cardinals: Despite a strong team batting average, they’ve struggled to convert hits into runs, particularly on the road.

• Reds: Coming off a sweep in Colorado, their offense showed signs of life, but overall consistency remains an issue.

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Cardinals vs Reds Moneyline

I think a moneyline bet is the best way to bet this game and I am leaning to the Reds as they are playing the better baseball as of right now, and they will score more runs.

DraftKings

4.6/5

Tip: Bet Reds ML

• Bullpen will be a major key
• Reds Hitting better
• Reds at home

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Cardinals vs Reds Over/Under Analysis

I would lean towards the over in this game as the pitching matchup highly favors a high-scoring game.

DraftKings

4.6/5

Tip: Bet the Over 7.59

• Cardinals Starting Pitcher will struggle
• Reds are hot
• Bullpen will be key

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Conclusion

Given the Reds’ offensive prowess and the Reds current hot streak, you have to feel comfortable betting the Reds tonight.  Reds 8  Cardinals 4

Bet Reds ML