MLB Cincinnati Reds vs Pittsburgh Pirates: Odds, Tips and Predictions 05-21-25

Today, the Reds and Pirates wrap up a three-game series in Pittsburgh. The Reds won game one of this series, while last night the Pirates bounced back to take the second game 1-0.

Cincinnati Reds vs Pittsburgh Pirates

• Run Line: Reds -1.5
• Moneyline Reds -126
• Moneyline Pirates +106
• Over/Under 8

These odds were updated at 9 am EST on 05/21/25, coming from DraftKings. Check out the top online MLB betting sites the only way to be great at sports betting is to have multiple accounts with at least three sportsbooks to get the best odds for every game.

⚾ Pitching Matchup

• Reds: Brady Singer (5-2, 5.01 ERA)

  • Singer has a 2-1 record with a 6.32 ERA in his career against the Pirates.

• Pirates: Andrew Heaney (2-3, ERA not specified)

  • Heaney has a 42% chance of delivering a quality start, according to AccuScore simulations.

📊 Team Performance

• Reds (25-25):

  • Batting average: .243

  • On-base percentage: .319

  • Slugging percentage: .395

  • Team ERA: 3.49

  • WHIP: 1.16

  • Key players: TJ Friedl (49 hits, 18 RBIs), Elly De La Cruz, Gavin Lux

• Pirates (16-33):

  • Batting average: .216

  • On-base percentage: .297

  • Slugging percentage: .318

  • Team ERA: 4.03

  • WHIP: 1.26

  • Key players: Ke’Bryan Hayes (42 hits, 15 RBIs), Bryan Reynolds, Isiah Kiner-Falefa

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Reds vs Pirates Moneyline

I think a moneyline bet is the best way to bet this game and I am leaning to the Reds as they are playing the better baseball as of right now, and they will score more runs.

DraftKings

4.5/5

Tip: Bet Reds ML

• Reds starting pitching advantage
• Reds Hitting better
• Pirates at home

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Reds vs Pirates Over/Under Analysis

I would lean towards the over in this game as the pitching matchup highly favors a high-scoring game.

DraftKings

4.5/5

Tip: Bet the Over 8

• Pirates Starting Pitcher will struggle
• Singer has struggled at times
• Bullpen will be key

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Conclusion

Given the Reds’ have the starting pitching edge and a good bullpen I expect a Reds victory once again. Expect a high scoring win. Reds 7  Pirates 4

Bet Reds ML