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The Grueling Truth - Where Legends Speak / Betting Tips / Top 4 Prop Bets: Indiana vs. Michigan State

Top 4 Prop Bets: Indiana vs. Michigan State

NCAAF Betting Tips · - ·

Publish Date: 10/17/2025
Fact checked by: Simon Briffa

This Saturday’s clash in the Big Ten pits the Indiana Hoosiers against the Michigan State Spartans in what could be a momentum-shifting matchup. Indiana turns over the keys to Fernando Mendoza, who’s taken the helm after his transfer from California. Michigan State counters with Aidan Chiles, a dual-threat quarterback who gives the Spartans flexibility. With both offenses showing flashes this season, several prop angles stand out.

Here are four bets that look compelling ahead of kickoff.

Fernando Mendoza Over 259.5 Passing Yards

Mendoza has been electric this season, completing big throws and managing tempo. Indiana’s aerial attack leans on intermediate and vertical concepts, often releasing the ball quickly when the protection breaks. Michigan State’s pass defense has had lapses in coverage, especially against play-action and rolling pockets. If Indiana builds a lead or needs to chase, Mendoza should surpass this mark.

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Tip: Fernando Mendoza over 259.5 passing yards
  • Mendoza in form
  • Indiana airing it out
  • MSU coverage lapses
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Aidan Chiles Over 32.5 Rushing Yards

Chiles brings rushing value to his role, and Indiana’s defense has shown some over-pursuit against mobile QBs. With blitzes or stunts collapsing the pocket, Chiles should be able to escape and pick up yardage on the ground. On key downs, expect some designed quarterback runs or scrambles. The Over 32.5 rushing yards is appealing in that light.

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Tip: Aidan Chiles over 32.5 rushing yards
  • Dual-threat QB
  • Pressure likely
  • Escape lanes available
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Jaylin Lucas Over 87.5 Total Yards

Lucas is Indiana’s do-it-all playmaker, contributing heavily in both the run and pass games. Against Michigan State, he should see touches as a runner, receiver, and even in screens—especially if MSU’s perimeter defenders cheat up. With volume and mismatch potential, Lucas has a strong chance to hit this all-purpose total.

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Tip: Jaylin Lucas over 87.5 total yards
  • Lucas usage heavy
  • Versatile role
  • Matchups favor him
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Omari Kelly Anytime Touchdown (+155)

One of Michigan State’s receiving options this season is Omari Kelly. Kelly has red-zone appeal and is likely to see targets inside the 20, especially if the Spartans lean on their passing game in scoring territory. Given Mendoza’s aggressiveness, and MSU’s desire to respond, Kelly getting into the end zone is a solid anytime play.

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Tip: Omari Kelly anytime touchdown (+155)
  • Kelly red-zone option
  • Mendoza aggressive
  • TD opportunity
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Conclusion

Indiana vs. Michigan State has the makings of a fast-paced, offense-driven affair. Mendoza’s arm opens the door for passing yard props, while Chiles offers scrambling upside. Lucas is key for Indiana’s balance, and Kelly is a budding red-zone target for MSU. Expect a game script that encourages quarterback production and touchdown chances — prime environment for prop bettors looking for value.

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