San Francisco 49ers vs Philadelphia Eagles Prediction, Odds & Picks – January 11, 2026

49ers (12-5-0) travel to face the Eagles (11-6-0) on Sunday at Lincoln Financial Field, with kickoff set for 04:30 pm ET. Both teams enter this matchup after losses in their previous games.

The Eagles are favored by -5.5 points, placing the 49ers in an underdog role from a betting perspective. Both teams have shown mixed results against the spread in recent weeks.

Below, you’ll find key betting stats and information to consider before placing any wagers on this matchup.

Eagles vs 49ers: Need to Know Stats

Below is a look at how both teams have performed this season, with records covering straight-up results, against-the-spread outcomes, totals, and recent form.

Best Odds For Eagles vs 49ers

The current betting market lists Eagles as the favorite, laying -5.5 points against the spread. On the moneyline, Eagles are priced at -235, while 49ers are available at +194. These prices reflect the pregame market positioning for this matchup based on available sportsbook listings.

Get a full market snapshot for NFL odds as Eagles meet 49ers. Explore top-rated football betting platforms in our trusted NFL sportsbooks to compare.

Season Records & Win Probabilities

The numbers put the Eagles in front. 11-6 and 67% carry them ahead of the 49ers at 12-5 and 33%.

Recent Form & Momentum

The have done more damage lately, with a 4–1 record that tops the 3–2 posted by the . Recent results tilt toward the road locker room.

Eagles vs 49ers Offensive Stats Breakdown

Offensively, this game should test how each side blends the run and the pass. bring a ground game headlined by Jalen Hurts, who has contributed 421 rushing yards at 4 yards per carry with 8 rushing TDs . answer with Christian McCaffrey driving their rushing totals with 1202 yards at 4 a pop and 10 scores on the ground .

Passing Matchup

On the stat sheet, Jalen Hurts accounts for 3224 passing yards and 25 TDs . Brock Purdy answers with 2167 yards and 20 scores .

Jalen Hurts and Christian McCaffrey sit at the top of the rushing charts for their teams.

Quarterback carries show up in the rushing data.

Receiving Matchup

This matchup features receiving leaders from separate position groups.

Jalen Hurts vs Brock Purdy Player Prop Odds

Quarterback rushing rushing-related props remain available regardless of game context. These lines continue to reflect individual rushing totals recorded in official play-by-play data.

Once the talk shifts to fronts, spacing, and who holds up in protection, it’s not long before someone brings up Super Bowl prop sheet.

Injury Report

According to the current injury report, the {{ fixture.home.name }} and {{ fixture.away.name }} have players are shown on. The full injury listing are outlined in the table below.